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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
31.21
Human Site:
Y937
Identified Species:
49.05
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
Y937
K
A
G
F
D
S
D
Y
D
Q
A
L
A
D
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
Y937
K
A
G
F
D
S
D
Y
D
Q
A
L
A
D
I
Dog
Lupus familis
XP_531814
1283
145094
R898
Y
W
G
I
G
R
N
R
Y
Q
L
E
I
P
E
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
Y934
K
A
G
F
D
S
D
Y
D
Q
A
L
A
D
I
Rat
Rattus norvegicus
XP_002726765
1361
151628
Y937
K
A
G
F
D
S
D
Y
D
Q
A
L
A
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
Y1043
K
A
G
F
D
P
D
Y
D
K
A
L
Q
D
I
Frog
Xenopus laevis
NP_001089247
1340
149481
Y917
K
A
G
F
D
P
D
Y
D
E
A
L
K
D
V
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
Y938
K
A
G
F
D
P
E
Y
D
Q
A
L
N
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
Q812
G
S
D
K
K
R
Y
Q
L
D
V
P
E
S
H
Honey Bee
Apis mellifera
XP_392346
1120
127429
K742
E
Q
Y
L
E
K
Q
K
K
H
F
G
V
K
I
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
K808
I
K
F
V
D
S
G
K
V
K
Y
L
L
E
M
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
Y909
C
K
G
V
I
P
E
Y
D
N
A
I
S
D
I
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
M902
I
G
S
V
S
A
S
M
P
I
K
A
G
R
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
Y891
H
E
G
A
D
E
E
Y
D
C
A
C
K
T
V
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
S864
E
V
R
A
L
A
R
S
M
A
E
A
K
E
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
13.3
N.A.
100
100
N.A.
N.A.
80
73.3
73.3
N.A.
0
6.6
20
40
P-Site Similarity:
100
N.A.
100
20
N.A.
100
100
N.A.
N.A.
86.6
86.6
80
N.A.
6.6
20
40
60
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
0
N.A.
N.A.
33.3
6.6
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
46.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
47
0
14
0
14
0
0
0
7
60
14
27
0
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% C
% Asp:
0
0
7
0
60
0
40
0
60
7
0
0
0
47
0
% D
% Glu:
14
7
0
0
7
7
20
0
0
7
7
7
7
14
7
% E
% Phe:
0
0
7
47
0
0
0
0
0
0
7
0
0
0
7
% F
% Gly:
7
7
67
0
7
0
7
0
0
0
0
7
7
7
0
% G
% His:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% H
% Ile:
14
0
0
7
7
0
0
0
0
7
0
7
7
0
60
% I
% Lys:
47
14
0
7
7
7
0
14
7
14
7
0
20
7
0
% K
% Leu:
0
0
0
7
7
0
0
0
7
0
7
54
7
0
0
% L
% Met:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
7
0
0
7
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
27
0
0
7
0
0
7
0
7
0
% P
% Gln:
0
7
0
0
0
0
7
7
0
40
0
0
7
0
0
% Q
% Arg:
0
0
7
0
0
14
7
7
0
0
0
0
0
7
0
% R
% Ser:
0
7
7
0
7
34
7
7
0
0
0
0
7
7
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% T
% Val:
0
7
0
20
0
0
0
0
7
0
7
0
7
0
14
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
7
0
0
0
7
60
7
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _